Computational Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland peter.wurtz@computationalmedicine.fi. Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. Computational Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland. NMR Metabolomics Laboratory, University of Eastern Finland, Kuopio, Finland. Finnish Institute of Occupational Health, Helsinki, Finland. Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland. Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland. Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland. National Institute for Health and Welfare, Helsinki, Finland. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. University of Tartu, Estonian Genome Center, Tartu, Estonia. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany. German Center for Cardiovascular Research, Lübeck, Kiel, Germany. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. Center for Life Course Health Research and Biocenter Oulu, University of Oulu, Oulu, Finland. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Computational Medicine, University of Bristol, Bristol, UK. Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. Department of Community Medicine, UiT Arctic University of Norway, Tromsø, Norway.